Cayman Chemokine-Like Receptor 1 Blocking Peptide

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues.^, Chemerin (TIG2) has been identified as the natural ligand for this receptor. Resolvin E1 has also been identified as a ligand for CMKLR1; acting to dampen cellular responses to inflammation.^,, Chemerin is an 18 kDa protein that plays a role in immunity, inflammation, chemotaxis, and has been identified as an adipokine.^,, Human CMKLR1 shares 80% sequence homology with its murine ortholog. The human receptor exists in two isoforms, differing only by two amino acids due to a premature stop codon. Isoform one has 363 amino acids and an expected molecular weight of 42.3 kDa. Cayman’s CMKLR1 polyclonal antibody recognizes the C-terminal region of the protein and cell permeabilization is recommended prior to whole cell staining.

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