Cayman LY411575

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC₅₀ = 0.14 nM) that has been shown to block Notch activation in vitro at 500 µM.^1,2 LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis.^2,3 It has also been observed to promote neural differentiation of mouse embryonic stem cells.⁴

WARNING This product is not for human or veterinary use.