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Cayman EPZ6438
List Price
$264.00
Your Price
$264.00
Cayman EPZ6438 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16174-50
MFG.PART:
16174-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
EPZ6438 is an orally bioavailable, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 2.5 nM), the enzymatic subunit of polycomb repressive complex 2.1 It displays a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other histone methyltransferases.1 EPZ6438 blocks histone H3 lysine 27 trimethylation in both wild-type and mutant lymphoma cells (IC50s range from 2-90 nM).2 EPZ6438 has been shown to induce apoptosis and differentiation specifically in SMARCB1-deleted malignant rhabdoid tumor cells and to promote their regression in xenograft-bearing mice.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4-(4-morpholinylmethyl)-[1,1-biphenyl]-3-carboxamide
CAS Number
1403254-99-8
Synonyms
- Tazemetostat
Molecular Formula
C34H44N4O4
Formula Weight
572.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 10 mg/mL
λmax
256 nm
SMILES
CC(C(N(C1CCOCC1)CC)=C2)=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C2C4=CC=C(CN5CCOCC5)C=C4
InChi Code
InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
InChi Key
NSQSAUGJQHDYNO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16174-50 |
|---|---|
| Supplier Part Number | 16174-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1403254-99-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |