Cayman p-nitro-Pifithrin-α

Pifithrin-α (Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.¹ p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α.² It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α.² p-nitro-Pifithrin-α, at 10 µM, suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet.^3,4 It is slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-α, when incubated in biological media (t_½ = 8 H).²

WARNING This product is not for human or veterinary use.