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Cayman CYT387
List Price
$90.00
Your Price
$90.00
Cayman CYT387 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16246-1
MFG.PART:
16246-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively)., It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines. It is efficacious in a mouse model of JAK2V617F-dependent myeloproliferative neoplasms, although kinase domain mutations can confer resistance., CYT387 also blocks paclitaxel-induced JAK2 activation in ovarian cancer cells, preventing the development of a cancer stem cell-like population following chemotherapy.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
1056634-68-4
Synonyms
- Momelotinib
Molecular Formula
C23H22N6O2
Formula Weight
414.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 14 mg/mL
- DMSO: 16 mg/mL
λmax
292 nm
SMILES
O=C(NCC#N)C(C=C1)=CC=C1C2=NC(NC(C=C3)=CC=C3N4CCOCC4)=NC=C2
InChi Code
InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
InChi Key
ZVHNDZWQTBEVRY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16246-1 |
|---|---|
| Supplier Part Number | 16246-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1056634-68-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |