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Cayman JW 55
List Price
$134.00
Your Price
$134.00
Cayman JW 55 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16260-10
MFG.PART:
16260-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 µM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-
CAS Number
664993-53-7
Synonyms
- Tankyrase 1/2 Inhibitor IV
Molecular Formula
C25H26N2O5
Formula Weight
434.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
- Ethanol: 1 mg/mL
λmax
291 nm
SMILES
O=C(NCC1(C2=CC=C(OC)C=C2)CCOCC1)C3=CC=C(NC(C4=CC=CO4)=O)C=C3
InChi Code
InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
InChi Key
ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16260-10 |
|---|---|
| Supplier Part Number | 16260-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 664993-53-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |