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Cayman PBIT
List Price
$41.00
Your Price
$41.00
Cayman PBIT - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16272-1
MFG.PART:
16272-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). It does not significantly affect the activity of UTX and JMJD3 demethylases. It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
CAS Number
2514-30-9
Synonyms
- 2-p-tolyl-1,2-Benzisothiazolin-3-one
Molecular Formula
C14H11NOS
Formula Weight
241.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.1 mg/mL
- Ethanol: 1 mg/mL
λmax
259, 331 nm
SMILES
O=C1C2=CC=CC=C2SN1C3=CC=C(C)C=C3
InChi Code
InChI=1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
InChi Key
KRXMYBAZKJBJAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16272-1 |
|---|---|
| Supplier Part Number | 16272-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2514-30-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |