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Cayman SB-525334
List Price
$609.00
Your Price
$609.00
Cayman SB-525334 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16281-50
MFG.PART:
16281-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM).1 It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6.1 SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression.1 It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis.1,2,3 SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.3,4,5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-quinoxaline
CAS Number
356559-20-1
Synonyms
- TGF-β RI Kinase Inhibitor VIII
Molecular Formula
C21H21N5
Formula Weight
343.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
λmax
235, 365 nm
SMILES
CC(C)(C)C(N1)=NC(C2=CC=CC(C)=N2)=C1C(C=C3)=CC4=C3N=CC=N4
InChi Code
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChi Key
DKPQHFZUICCZHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16281-50 |
|---|---|
| Supplier Part Number | 16281-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 356559-20-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |