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Cayman TCS PIM-1 1
List Price
$740.00
Your Price
$740.00
Cayman TCS PIM-1 1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16286-100
MFG.PART:
16286-100
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC50s = >20 µM).1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile
CAS Number
491871-58-0
Synonyms
- Pim-1 Kinase Inhibitor II
- SC-204330
Molecular Formula
C18H11BrN2O2
Formula Weight
367.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
λmax
370 nm
SMILES
O=C1NC(C2=C(O)C=CC(Br)=C2)=CC(C3=CC=CC=C3)=C1C#N
InChi Code
InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
InChi Key
SVSYJTYGPLVUOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16286-100 |
|---|---|
| Supplier Part Number | 16286-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 491871-58-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |