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Cayman XL888
List Price
$54.00
Your Price
$54.00
Cayman XL888 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16309-1
MFG.PART:
16309-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. XL888 is an ATP-competitive inhibitor of Hsp90. Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.,, XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N1-[(3-endo)-8-[5-(cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-1,4-benzenedicarboxamide
CAS Number
1149705-71-4
Molecular Formula
C29H37N5O3
Formula Weight
503.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2)(1:5): 0.1 mg/mL
λmax
220, 265, 325 nm
SMILES
CC1=CC(C(N)=O)=C(N[C@H](C)CC)C=C1C(N[C@@H]2C[C@@H](N3C4=NC=C(C(C5CC5)=O)C=C4)CC[C@@H]3C2)=O
InChi Code
InChI=1S/C29H37N5O3/c1-4-17(3)32-25-14-23(16(2)11-24(25)28(30)36)29(37)33-20-12-21-8-9-22(13-20)34(21)26-10-7-19(15-31-26)27(35)18-5-6-18/h7,10-11,14-15,17-18,20-22,32H,4-6,8-9,12-13H2,1-3H3,(H2,30,36)(H,33,37)/t17-,20-,21+,22-/m1/s1
InChi Key
LHGWWAFKVCIILM-HLRQEUIKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16309-1 |
|---|---|
| Supplier Part Number | 16309-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1149705-71-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |