Cayman (S)-Ketoprofen

Ketoprofen (Item No. ) is a non-selective, non-steroidal, anti-inflammatory drug exhibiting IC₅₀ values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2 (Item No. ), respectively. Ketoprofen is commonly used in vivo as a racemic mixture of (R)- and (S)-enantiomers. (S)-Ketoprofen is a potent inhibitor of COX-1 and COX-2 (IC₅₀s = 1.9 and 27 nM, respectively), whereas the (R)-enantiomer is 100 to 1,000 times less potent.^, Notably, (S)-ketoprofen is known to be formed from the (R)-enantiomer in several animal species, except in humans and guinea pigs. Also, the pharmacokinetics of ketoprofen enantiomers and their glucuronide metabolites are altered in humans with rheumatoid arthritis or renal disease.^,

WARNING This product is not for human or veterinary use.