Cayman Doripenem (hydrate)

Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.^1,2 It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, <0.015-0.3, and 0.03-0.06 µg/mL, respectively).^1,2,3,4 Doripenem reduces the number of viable bacteria in mouse lung in a model of chronic P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.⁵ It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.² Formulations containing doripenem have been used in the treatment of bacterial infections.

WARNING This product is not for human or veterinary use.