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Cayman Astemizole
List Price
$102.00
Your Price
$102.00
Cayman Astemizole - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16967-50
MFG.PART:
16967-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Astemizole is a non-sedating antihistamine that antagonizes the histamine H1 receptor with a Ki value of 4.4 nM.1 It is considerably less potent at muscarinic acetylcholine receptors (Ki = 2.4 µM).2 Astemizole is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channels (IC50 = ~1 nM) that has been used to study long QT syndrome type 2.3,4 Furthermore, because it can target oncogenic ERG1 and ERG potassium channels, astemizole has been explored as a potential antineoplastic agent for decreasing proliferation of various cancer cells.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
CAS Number
68844-77-9
Synonyms
- NSC 329963
Molecular Formula
C28H31FN4O
Formula Weight
458.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 5 mg/mL
λmax
215, 250, 285 nm
SMILES
COC1=CC=C(CCN2CCC(NC3=NC4=C(C=CC=C4)N3CC5=CC=C(F)C=C5)CC2)C=C1
InChi Code
InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
InChi Key
GXDALQBWZGODGZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16967-50 |
|---|---|
| Supplier Part Number | 16967-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 68844-77-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |