Cayman Skepinone-L

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC₅₀s = 5 nM) and p38β (97% inhibition at 1 µM).^, It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin (Item No. ) in HeLa cells (IC₅₀ = 25 nM) or TNF-α in THP-1 cells.^, At 1 µM, it prevents phosphorylation of cytosolic phospholipase A₂ in platelets in response to collagen-related peptide or thrombin (Item No. ), blunting platelet secretion and aggregation.

WARNING This product is not for human or veterinary use.