Cayman Perhexiline (maleate)

Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s.^,, It inhibits rat heart and liver CPT1 (IC₅₀ = 77 and 148 µM, respectively) and rat heart CPT2 (IC₅₀ = 79 µM).^, Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.

WARNING This product is not for human or veterinary use.