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Cayman SP-141
List Price
$49.00
Your Price
$49.00
Cayman SP-141 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17003-1
MFG.PART:
17003-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP-141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP-141 promotes its auto-ubiquitination and proteasomal degradation., SP-141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo., This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
CAS Number
1253491-42-7
Synonyms
- AGN-PC-0D106I
Molecular Formula
C22H16N2O
Formula Weight
324.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 100 mg/mL
- Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL
λmax
221, 300, 365 nm
SMILES
COC1=CC2=C(C=C1)NC(C2=CC=N3)=C3C4=C(C=CC=C5)C5=CC=C4
InChi Code
InChI=1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChi Key
AABFWJDLCCDJJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17003-1 |
|---|---|
| Supplier Part Number | 17003-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1253491-42-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |