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Cayman TUG-891
List Price
$183.00
Your Price
$183.00
Cayman TUG-891 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17035-10
MFG.PART:
17035-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TUG-891 is an agonist of free fatty acid receptor 4 (FFAR4/GPR120; EC50s = 0.0436 and 0.0169 µM for the human and mouse receptors, respectively).1 It is selective for FFAR4 over FFAR1/GPR40 (EC50 = 64.5 µM for the human receptor) and is inactive against FFAR2/GPR43 and FFAR3/GPR41. TUG-891 (1 µM) inhibits lysophosphatidic acid- or EGF-induced proliferation and migration of DU145 and PC3 prostate cancer cells.2 It stimulates glucagon-like peptide 1 (GLP-1) release in STC-1 enteroendrocrine cells and glucose uptake in 3T3-L1 adipocytes, as well as inhibits LPS-induced TNF-α release in RAW 264.7 macrophages when used at a concentration of 10 µM.3 TUG-891 (20 mg/kg) reduces sleep fragmentation-induced increases in food consumption and epididymal fat mass in mice.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(4-fluoro-
CAS Number
1374516-07-0
Molecular Formula
C23H21FO3
Formula Weight
364.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:5): 0.1 mg/mL
- Ethanol: 1 mg/mL
SMILES
CC1=CC=C(C2=CC=C(F)C=C2COC3=CC=C(CCC(O)=O)C=C3)C=C1
InChi Code
InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
InChi Key
LPGBXHWIQNZEJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17035-10 |
|---|---|
| Supplier Part Number | 17035-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1374516-07-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |