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Cayman GSK4716
List Price
$71.00
Your Price
$71.00
Cayman GSK4716 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17233-10
MFG.PART:
17233-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-hydroxy-2-[[4-(1-methylethyl)phenyl]methylene]hydrazide benzoic acid
CAS Number
101574-65-6
Molecular Formula
C17H18N2O2
Formula Weight
282.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 16 mg/mL
- Ethanol: 20 mg/mL
- Ethanol:PBS (pH 7.2) (1:6): 0.14 mg/mL
λmax
220, 309 nm
SMILES
OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1
InChi Code
InChI=1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+
InChi Key
IKPPIUNQWSRCOZ-WOJGMQOQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17233-10 |
|---|---|
| Supplier Part Number | 17233-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 101574-65-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |