Cayman Thyroid Hormone Receptor Antagonist (1-850); Purity- Great

Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.^,, It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC₅₀s = 21, 370, 120, 70, and 400 μM, respectively). Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells. Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC₅₀s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.^,

WARNING This product is not for human or veterinary use.