Cayman Ic261; Purity- Greater Than Or Equal To 95%; Size- 10 Mg;

LY320135 is a selective cannabinoid (CB) receptor 1 antagonist (K_is = 224 and >10,000 nM for CB₁ and CB₂, respectively, in vitro). It is selective for CB₁ over α₁- and α₂- adrenergic, D₁ and D₂ dopamine, benzodiazepine, histamine H₁, GABA, serotonin (5-HT), and muscarinic receptors. It reverses the inhibition of forskolin-induced cAMP accumulation induced by arachidonoyl ethanolamide (anandamide; Item No. ) in CHO cells and inhibits a stimulatory effect of arachidonoyl ethanolamide on adenylate cyclase induced by application of pertussis toxin (IC₅₀ = 734 nM). LY320135 (1 mg/kg) reverses inhibition of light-induced phase shifts in hamsters induced by the CB₁ agonist CP 55,940 (Item No. ).

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