Cayman Imd 0354; Purity- Greater Than Or Equal To 98%; Size- 10 M

IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC₅₀ = ~250 nM) and subsequent NF-κB p65 nuclear translocation.¹ It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury.¹ IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis.² It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 µM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.³

WARNING This product is not for human or veterinary use.