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Cayman (E/Z)-4-hydroxy Tamoxifen
List Price
$293.00
Your Price
$293.00
Cayman (E/Z)-4-hydroxy Tamoxifen - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17308-50
MFG.PART:
17308-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Item No. 13258).1 It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively).2 It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-
CAS Number
68392-35-8
Synonyms
- Afimoxifene
- 4-OHT
Molecular Formula
C26H29NO2
Formula Weight
387.5
Purity
≥98% (mixture of isomers)
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 2 mg/mL
- Ethanol: 20 mg/mL
- Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/mL
λmax
246, 287 nm
SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3
InChi Code
InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChi Key
TXUZVZSFRXZGTL-QPLCGJKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17308-50 |
|---|---|
| Supplier Part Number | 17308-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 68392-35-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |