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Cayman Bms 754807; Purity- Greater Than Or Equal To 98%; Size- 5
List Price
$202.00
Your Price
$202.00
Cayman Bms 754807; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17505-5
MFG.PART:
17505-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively).1,2 It has minimal effect against an array of other tyrosine and serine/threonine kinases.1 BMS 754807 inhibits cell proliferation or induces apoptosis in a variety of cancer cells in vitro.2 It inhibits the growth of tumor xenografts in mice and this effect is often enhanced by combination therapy with other chemotherapeutics.2,3,4 Predictive biomarkers, including elevated IGF-1R expression, for effectiveness of BMS 754807 have been delineated.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyrrolidinecarboxamide
CAS Number
1001350-96-4
Molecular Formula
C23H24FN9O
Formula Weight
461.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
244, 312 nm
SMILES
FC1=NC=C(NC([C@]2(C)CCCN2C3=NN4C(C(NC5=NNC(C6CC6)=C5)=N3)=CC=C4)=O)C=C1
InChi Code
InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1
InChi Key
LQVXSNNAFNGRAH-QHCPKHFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17505-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 17505-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1001350-96-4 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |