We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Trans-Ned-19; Purity- Greater Than Or Equal To 98%; Size-
List Price
$321.00
Your Price
$321.00
Cayman Trans-Ned-19; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17527-10
MFG.PART:
17527-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative breast cancer, mantel cell lymphoma, multiple myeloma, non-Hodgkins, and acute myeloid leukemia cell lines. It inhibits expression of prostate specific antigen (PSA) and H3K27Ac occupancy at the PSA enhancer without inhibiting androgen receptor occupancy in LNCaP-FGC cells. A-485 reduces tumor volume in a LuCaP-77 mouse xenograft model of castration-resistant prostate cancer when administered at a dose of 100 mg twice per day for 21 days.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1R)-N-[(4-
CAS Number
1889279-16-6
Molecular Formula
C25H24F4N4O5
Formula Weight
536.5
Purity
≥98% (mixture of isomers)
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 16 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
253 nm
SMILES
O=C(NC)NC1=CC=C2C(CC[C@]23C(N(CC(N(CC4=CC=C(F)C=C4)[C@@H](C)C(F)(F)F)=O)C(O3)=O)=O)=C1
InChi Code
InChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14?,24-/m1/s1
InChi Key
VRVJKILQRBSEAG-PYFQUHSISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17527-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 17527-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1354235-96-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |