Cayman N-4-Tosyl-L-Arginine Methyl Ester (Hydrochloride); Purity-

GW 311616A is an inhibitor of neutrophil elastase (IC₅₀ = 100 nM). It is selective for neutrophil elastase (IC₅₀ = 22 nM for the human enzyme) over trypsin, cathepsin G, and plasmin (IC₅₀s = >100 µM for all), as well as chymotrypsin and tissue plasminogen activator (IC₅₀s = >3 µM for both), in cell-free assays. GW 311616A (20 µM) inhibits the formation of neutrophil extracellular traps (NETs) induced by phorbol 12-myristate 13-acetate (PMA; Item No. ) in isolated human neutrophils. It inhibits intraneutrophil elastase activity in isolated dog blood six hours after administration of a 0.22 mg/kg dose. GW 311616A also inhibits neutrophil elastase in the liver in a mouse model of liver ischemia-reperfusion injury when administered at a dose of 2 mg/kg.

WARNING This product is not for human or veterinary use.