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Cayman NI-57
List Price
$36.00
Your Price
$36.00
Cayman NI-57 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17662-1
MFG.PART:
17662-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators., BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system. NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. It is selective for BRPFs over other bromodomains. NI-57 shows accelerated FRAP recovery at 1 µM in the BRPF2 FRAP assay, preventing binding of full-length BRPF2 to chromatin. See the website for more information.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-cyano-N-
CAS Number
1883548-89-7
Molecular Formula
C19H17N3O4S
Formula Weight
383.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 25 mg/mL
λmax
210, 236, 279, 310, 334 nm
SMILES
COC1=CC(C#N)=CC=C1S(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)(=O)=O
InChi Code
InChI=1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3
InChi Key
UEMQPCYDWCSVCU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17662-1 |
|---|---|
| Supplier Part Number | 17662-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1883548-89-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |