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Cayman NMS-873
List Price
$42.00
Your Price
$42.00
Cayman NMS-873 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17674-1
MFG.PART:
17674-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[3-(cyclopentylthio)-5-[[[2-methyl-4-(methylsulfonyl)[1,1-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-pyridine
CAS Number
1418013-75-8
Synonyms
- VCP Inhibitor III
Molecular Formula
C27H28N4O3S2
Formula Weight
520.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 0.5 mg/mL
λmax
266 nm
SMILES
CC1=C(C2=CC=C(S(C)(=O)=O)C=C2)C=CC(OCC3=NN=C(SC4CCCC4)N3C5=CN=CC=C5)=C1
InChi Code
InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3
InChi Key
UJGTUKMAJVCBIS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17674-1 |
|---|---|
| Supplier Part Number | 17674-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1418013-75-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |