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Cayman ELR510444
List Price
$527.00
Your Price
$527.00
Cayman ELR510444 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17696-25
MFG.PART:
17696-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
ELR510444 is an inhibitor of tubulin polymerization (IC50 = 10 μM) that binds to tubulin at the colchicine (Item No. 9000760) binding site.1 It induces microtubule depolymerization in A-10 cells (EC50 = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1α (HIF-1α) in RCC4 cells in a concentration-dependent manner.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[5-(5-cyano-
CAS Number
1233948-35-0
Molecular Formula
C19H16N2O2S2
Formula Weight
368.5
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- Methyl Acetate: 10 mg/mL
λmax
309 nm
SMILES
CC1=CC=C(S(NC2=C(C)C=CC(C3=CC=C(C#N)S3)=C2)(=O)=O)C=C1
InChi Code
InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3
InChi Key
GRYXROIHHXHFND-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17696-25 |
|---|---|
| Supplier Part Number | 17696-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1233948-35-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |