Cayman 2-Acetamidophenyl 5-Chloro-2-Nitrophenyl Sulfide; Purity-

VTP-27999 is a renin inhibitor (IC₅₀ = 0.47 nM for the recombinant human enzyme). It is selective for renin over the aspartyl proteases β-secretase, cathepsin D, and cathepsin E at 10 µM and is greater than 1,000-fold selective for renin over a panel of more than 250 receptors, ion channels, and enzymes. VTP-27999 (10 mg/kg, p.o.) reduces mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension.

WARNING This product is not for human or veterinary use.