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Cayman GSK2334470
List Price
$84.00
Your Price
$84.00
Cayman GSK2334470 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18095-5
MFG.PART:
18095-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that plays an important role in growth factor signaling by phosphorylating and activating a group of kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. GSK2334470 is an inhibitor of PDK1 (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members.1 In HEK293 cells, 30 nM - 1 µM GSK2334470 suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3S,6R)-1-
CAS Number
1227911-45-6
Molecular Formula
C25H34N8O
Formula Weight
462.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 20 mg/mL
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/mL
λmax
226, 258, 328 nm
SMILES
NC1=NNC2=CC(C3=CC(N4C[C@@H](C(NC5CCCCC5)=O)CC[C@H]4C)=NC(NC)=N3)=CC=C21
InChi Code
InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
InChi Key
QLPHOXTXAKOFMU-WBVHZDCISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18095-5 |
|---|---|
| Supplier Part Number | 18095-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1227911-45-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |