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Cayman JYL1421
List Price
$470.00
Your Price
$470.00
Cayman JYL1421 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-20458-10
MFG.PART:
20458-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).1 It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO Cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).2 It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[[[[[[4-
CAS Number
401907-26-4
Molecular Formula
C20H26FN3O2S2
Formula Weight
423.6
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO:
λmax
225 nm
SMILES
CC(C)(C)C1=CC=C(CNC(NCC2=CC(F)=C(NS(C)(=O)=O)C=C2)=S)C=C1
InChi Code
InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
InChi Key
DUHBVFMCIJLUJX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-20458-10 |
|---|---|
| Supplier Part Number | 20458-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 401907-26-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |