Cayman Tazarotene

Tazarotene is a retinoid prodrug of tazarotenic acid (Item No. 21367).¹ It is metabolized by esterases in vivo to its active free acid form. Tazarotene (1 μM) inhibits proliferation of and collagen synthesis by human dermal fibroblasts in vitro.² It also downregulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation and upregulates tazarotene-induced gene 1 (TIG1) and TIG2 in patient-derived psoriatic lesion samples following topical administration.³ Tazarotene (0.1% per day, topical) induces complete reduction in skin utricle diameter in the Rhino mouse, which is a model used to test retinoid activity because its skin contains keratinized pilosebaceous structures.⁴ It also decreases basal cell carcinoma number and size in a Ptch1+/- mouse model of ultraviolet- or ionizing radiation-induced skin cancer when administered topically at a dose of 0.1% per day.⁵ Formulations containing tazarotene have been used in the treatment of psoriasis, acne, and sun-damaged skin.

WARNING This product is not for human or veterinary use.