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Cayman Lu AF21934
List Price
$49.00
Your Price
$49.00
Cayman Lu AF21934 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27045-1
MFG.PART:
27045-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Lu AF21934 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4; EC50 = 500 nM for the human receptor in a FLIPR assay). It is selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels, g protein-coupled receptors (GPCRs), and enzymes at 10 μM. Lu AF21934 (12 mg/kg) reduces marble burying behavior and stress-induced hyperthermia in mice, indicating anxiolytic-like activity, but also reduces locomotor activity. It inhibits MK-801- and amphetamine-induced hyperactivity in mice and prevents MK-801-induced decreases in social interaction in rats. Lu AF21934 (0.5 and 2.5 mg/kg) also reduces harmaline-induced hyperactivity, but not tremor, in rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N1-(3,4-
CAS Number
1445605-23-1
Molecular Formula
C14H16Cl2N2O2
Formula Weight
315.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:4): 0.20 mg/mL
λmax
211, 252 nm
SMILES
O=C(NC1=CC(Cl)=C(Cl)C=C1)[C@@H]2[C@H](C(N)=O)CCCC2
InChi Code
InChI=1S/C14H16Cl2N2O2/c15-11-6-5-8(7-12(11)16)18-14(20)10-4-2-1-3-9(10)13(17)19/h5-7,9-10H,1-4H2,(H2,17,19)(H,18,20)/t9-,10+/m1/s1
InChi Key
AVKZWCJNDWOBAM-ZJUUUORDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27045-1 |
|---|---|
| Supplier Part Number | 27045-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1445605-23-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |