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Cayman Dihydrotetrabenazine
List Price
$253.00
Your Price
$253.00
Cayman Dihydrotetrabenazine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27182-1
MFG.PART:
27182-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine (Item No. ) that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,3,4,6,7,11b
CAS Number
3466-75-9
Synonyms
- DTBZ
- trans-(2,3)-Dihydro Tetrabenazine
Molecular Formula
C19H29NO3
Formula Weight
319.4
Purity
≥98% (mixture of isomers)
Formulation
A solid
Solubility
- Chloroform: soluble
- Methanol: soluble
SMILES
OC1C(CC(C)C)CN2C(C(C=C(OC)C(OC)=C3)=C3CC2)C1
InChi Code
InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3
InChi Key
WEQLWGNDNRARGE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27182-1 |
|---|---|
| Supplier Part Number | 27182-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 3466-75-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |