Cayman Cytokeratin 7 (C-Term) Rabbit Monoclonal Antibody (Clone RM416)

Cytokeratin 7 (CK-7) is an intermediate filament protein and a member of the cytokeratin protein family.^, It is a type II neutral-basic cytokeratin expressed in ductal, glandular, and transitional epithelial tissues, as well as endothelial cells, but not stratified squamous epithelia, and is localized to the cytoplasm.^, CK-7 is found in various tumors, including ductal, lobular, and mucinous carcinomas, as well as ovarian, but not colorectal, adenocarcinomas, malignant mesotheliomas, and transitional cell carcinomas. It is also found in chromophobe renal cell carcinomas but not oncocytoma and conventional carcinomas and has been used as a biomarker for differentiation of tumor origin. Hepatocyte expression of CK-7 is positively correlated with fibrosis stage in patients with hepatitis B and hepatitis C. Cayman’s Cytokeratin 7 (C-Term) Rabbit Monoclonal Antibody (Clone RM416) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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