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Millipore Anti-Mouse Bid Cleavage (59/60) Site Specific Antibody
Millipore Anti-Mouse Bid Cleavage (59/60) Site Specific Antibody
List Price$591.63Your Price$591.63
Millipore This Anti-Mouse Bid Cleavage (59/60) Site Specific Antibody Is Validated For Use In Wb For The Detection Of Mouse Bid Cleavage (59/60) Site Specific. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-mouse BID cleavage (59/60) site specific Antibody
Background Information
BH3 interacting domain death agonist (BID, 22 kDa) is a pro-apoptotic member of the Bcl-2 family. BID interacts with both Bcl-2 and Bax through its BH3 domain. It usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase-8 in response to TNF-α or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase-8 activation and mitochondrial death machinery.
Product Information
Format
Purified
Control
Mouse L929 (3T3-L1) cells treated with TNF-α to induce cleavage; caspase-8 cleaved recombinant mouse BID.
Presentation
Dulbeccos phosphate buffered saline (without mg2+ and Ca2+), pH 7.3 (+/- 0.1), 50% glycerol with 1.0 mg/mL BSA (IgG, protease free) as a carrier, 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-mouse BID cleavage (59/60) site specific Antibody is validated for use in WB for the detection of mouse BID cleavage (59/60) site specific.
Key Applications
Western Blotting
Biological Information
Immunogen
The antiserum was produced against a chemically synthesized peptide derived from the 15 kDa caspase-8 cleavage product of mouse BID.
Host
Rabbit
Specificity
Mouse 15 kDa caspase-8 cleavage product of BID. Human (75% conserved) BID has been tested and shown not to cross-react. Rat (100% conserved) and chicken (62% conserved) BID have not been tested.
Species Reactivity
Mouse
Antibody Type
Polyclonal Antibody
Gene Symbol
BID
UniProt Number
P70444
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at -20°C. We recommend a brief centrifugation before opening to settle vial contents. Then, apportion into working aliquots and store at -20°C. For shipment or short-term storage (up to one week), 2-8°C is sufficient.
