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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | DB, FC, IH(P) | Rb | Unpurified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB1560 |
| Replaces | MAB5330 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Opioid Receptor Antibody, δ, pain, NT |
| Background Information | Delta-type opioid receptor (UniProt: P32300; also known as D-OR-1, DOR-1, K56, MSL-2) is encoded by the Oprd1 gene (Gene ID: 18386) in murine species. Opioid receptors are seven-transmembrane proteins that which belong to the g protein-coupled receptor (GPCR) superfamily. Three types of opioid receptors have been described and are known as Mu ( ), Kappa ( ), and Delta ( ) receptors. Following binding to exogenous opiates and endogenous opioid peptides, such as β-endorphin, enkephalins and dynorphins, they are activated and transmit signals to multiple intracellular effectors, such as ion channels and second messengers that ultimately reduce neuronal activity. These receptors have a common opioid binding pocket within the helical transmembrane core. Opioid receptor delta (DOP) is a multi-pass transmembrane glycoprotein with four extracellular domains, seven transmembrane domains, and four cytoplasmic domains. They are highly concentrated in the basal ganglia and limbic regions of the brain. DOP are expressed in structures of both the ascending and the descending pain pathways. They participate not only in the control of pain, but are also involved in mood disorders, including anxiety and depression. Selective activation of the DOP is reported to have great potential for the treatment of chronic pain. (Ref.: Quirion, B., et Al. (2020). Front. Mol. Neurosci. 13; 52; Lutz, PE., and Kieffer, BI. (2013). Trends Neurosci. 36(3); 195-206; Pradhan, AA., et Al. (2011). Trends Pharmacol. Sci. 32(10); 581-590). |
| Product Information | |
|---|---|
| Format | Unpurified |
| Control |
|
| Presentation | Rabbit polyclonal antibody in serum with 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Opioid Receptor , pain, NT, Cat. No. AB1560, is a rabbit polyclonal antibody that detects Delta-type opioid receptor and is tested for use in DOT Blot and Immunohistochemistry (Paraffin). |
| Key Applications |
|
| Application Notes | Immunohistochemistry (Paraffin) Analysis: A 1:500 dilution from a representative lot detected Delta-type opioid receptor in Rat brain tissue sections. Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user |
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to 15 amino acids from the N-terminal region of mouse Opioid Receptor. |
| Epitope | N-terminus |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | This rabbit polyclonal antibody detects Delta Opioid Receptor. It targets an epitope within 15 amino acids from the N-terminal region. |
| Species Reactivity |
|
| Species Reactivity Note | Rat. Predicted to react with Mouse, Human based on 100% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Unpurified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P41143 # Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins. SIZE: 372 amino acids; 40413 Da SUBUNIT: Interacts with GPRASP1. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: P41143 ## Belongs to the g-protein coupled receptor 1 family. |
| Molecular Weight | 40.56 kDa calculated. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by DOT Blot with Delta opioid receptor, N-terminal peptide. DOT Blot Analysis: Various concentrations of Opioid Receptor Delta (12.5 to 200 ng) were detected using Cat. No. AB1560, Anti-Opioid Receptor , pain, NT. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Store at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Packaging Information | |
|---|---|
| Material Size | 50 µL |