Cell Signaling Il-6 (D5w4v) Xp Rabbit mAb (Mouse Specific) (Pe Conjugate)

Name: Cell Signaling Il-6 (D5w4v) Xp Rabbit mAb (Mouse Specific) (Pe Conjugate)
SKU: CSIG-13797S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Il-6 (D5w4v) Xp Rabbit mAb (Mouse Specific) (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13797S

MFG.PART: 13797S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	IL-6 (D5W4V) XP® Rabbit mAb (PE Conjugate) recognizes endogenous levels of total IL-6 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant mouse IL-6 protein.
Background	Acute phase response is induced by interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells (1,2). IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-β, is important for developing Th17 responses. IL-6 binds to IL-6Rα and through this association induces gp130 homodimerization (1). gp130 homodimerization triggers the Jak/Stat cascade and the SHP-2/Erk MAP kinase cascade (1,3,4). IL-6 also forms a complex with an IL-6Rα splice variant that is nonmembrane-associated (3). The IL-6/soluble IL-6Rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not IL-6Rα (3). Research studies have shown that IL-6, through increasing expression of proangiogenic VEGF, may also contribute to metastatic breast cancer (5).

Specifications