Cell Signaling Bmp4 (6b7) Mouse mAb

Name: Cell Signaling Bmp4 (6b7) Mouse mAb
SKU: CSIG-4680S
Price: 351.48 USD

List Price $351.48 Your Price $351.48

Cell Signaling Bmp4 (6b7) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4680S

MFG.PART: 4680S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Transfected Only
Molecular Weight (kDa)	47
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	BMP4 (6B7) Mouse mAb detects transfected levels of total BMP4 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a BMP4 fusion protein.
Background	Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation (1,2). BMPs belong to the TGF-β superfamily, playing many diverse functions during development (3). BMPs are synthesized as precursor proteins and then processed by cleavage to release the C-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5, and 8), resulting in the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems (3,4).BMP4 plays an essential role during development. Mouse embyros deficient in BMP4 die around the time of gastrulation (5). BMP4 regulates stem cell maintenance and differentiation in various systems (6-8).

Specifications