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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R, H | WB, IHC | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MABN371 |
| Description | Anti-KChIP2 potassium channel subunit Antibody, clone 60/73 |
| Alternate Names |
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| Background Information | KCHIP2, also known as Kv channel-interacting protein 2 (KChIP2), or A-type potassium channel modulatory protein 2, or Potassium channel-interacting protein 2, and encoded by the gene Kcnip2/Kchip2, is the regulatory subunit of the Kv4/D Shal-type voltage gated inactivating potassium channel. KCHIP2 modulates the activities of Kv4.2 and Kv4.3 potassium channels. KCHIP2 is localized to the cell membrane but is a peripheral membrane protein. KCHIP2 is expressed in heart, brain and lung. In brain, KCHIP2 is abundantly expressed in striatum, hippocampus, and olfactory bulb, but moderate to low expression is seen in cerebral cortex thalamus and hypothalamus. KCHIP2 has multiple isoforms in the different tissues. Isoform 1 is predominant in cerebral cortex, striatum and hippocampus, and all three isoforms are equally expressed in olfactory bulb, but in heart only isoform 3 predominates. |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-KChIP2 potassium channel subunit Antibody, clone 60/73 is validated for use in western blotting & IHC for the detection of KChIP2 potassium channel subunit. |
| Key Applications |
|
| Application Notes | Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KChIP2 potassium channel subunit in human cerebral cortex tissue. |
| Biological Information | |
|---|---|
| Immunogen | GST-tagged recombinant protein corresponding to rat KChIP2 potassium channel subunit. |
| Clone | 60/73 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | This antibody does not cross react with rat KChIP1 and KChIP3 (Prof. J. Trimmer, University of California, Davis). |
| Isotype | IgG1κ |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Protein g Purified |
| UniProt Number |
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| Molecular Weight | ~ 35 kDa observed. Uncharacterized band(s) may appear in some lysates. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected KChIP2 potassium channel subunit in 10 µg of mouse brain tissue lysate. |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |