Cell Signaling Nup88 (D7u4o) Rabbit mAb

Name: Cell Signaling Nup88 (D7u4o) Rabbit mAb
SKU: CSIG-13613S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Nup88 (D7u4o) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13613S

MFG.PART: 13613S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	88
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	NUP88 (D7U4O) Rabbit mAb recognizes endogenous levels of total NUP88 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly676 of human NUP88 protein.
Background	The nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1). The 88 kDa nucleoporin protein (NUP88) is located on the cytoplasmic side of the NPC and found to be a part of a subcomplex with the NUP214 NPC subunit (1-3). This NUP88/NUP214 subcomplex interacts with CRM-1/exportin-1 to play an important role in the export of proteins, including the 60S ribosomal particle from the nucleus (4,5). Research studies demonstrate elevated expression and cytoplasmic accumulation of NUP88, visible as granular dots, in ovarian, prostate, and breast cancers (6-9). Increased NUP88 levels correlate with higher tumor grade, suggesting that NUP88 may be a putative tumor marker (1,7).

Specifications