Cell Signaling Pcsk7 (D4i5g) Rabbit mAb

Name: Cell Signaling Pcsk7 (D4i5g) Rabbit mAb
SKU: CSIG-19346S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Pcsk7 (D4i5g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-19346S

MFG.PART: 19346S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	92
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PCSK7 (D4I5G) Rabbit mAb recognizes endogenous levels of total PCSK7 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu630 of human PCSK7 protein.
Background	PCSK7 (PC7) is a member of the subtilisin-like proprotein convertase family (1,2). Like other members of the family, the protein cleaves precursors at basic amino acids within the motif Arg/Lys-Xn-Arg (cleavage site) (n=2 or 4). PC7 was reported to be localized in the trans-golgi network and at the cell surface membrane, as well as in membrane internalized recycling vesicles (2,3). One function of PCSK7 is its critical role in growth factors processing, for example proEGF to EGF, proVEGF-C to VEGF-C, and BDNF neuropeptide maturation. PCSK7 is also involved in transferrin receptor shedding to regulate ion homeostasis (7,8) and MHC class I stability to regulate antigen presentation in the immunoresponse process (9).

Specifications