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MAPKAP Kinase Substrate Peptide primarily used in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Entrez Gene Number
NM_004759.3
NM_032960.2
Entrez Gene Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Gene Symbol
MAPKAPK2
MK2
MAPKAPK-2
Protein Target
MAPKAP
Target Sub-Family
CAMK
UniProt Number
P49137
UniProt Summary
FUNCTION: SwissProt: P49137 # Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at Ser-7 and tyrosine hydroxylase (on Ser-19 and Ser-40). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity. SIZE: 400 amino acids; 45568 Da SUBUNIT: Interacts with PHC2. TISSUE SPECIFICITY: Expressed in all tissues examined. PTM: Phosphorylated and activated by MAP kinase. SIMILARITY: SwissProt: P49137 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated as a substrate for MAPKAP Kinase 2, active (14-216 & 14-337). May also be used as a substrate for MAPKAP Kinase 1.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
