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Millipore Active, N-Terminal His6-Tagged, Recombinant Amino Acids 1-421 Of Human P70 S6 Kinase, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Expressed in Sf21 cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_003161.2,T412E
Entrez Gene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Gene Symbol
RPS6KB1
p70-alpha
p70S6k
p70-S6K
p70
S6K
S6Kalpha)
P70S6K
STK14A
S6K1
p70(S6K)-alpha
PS6K
Protein Target
p70S6K
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
AGC
UniProt Number
P23443
UniProt Summary
FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. SIZE: 525 amino acids; 59140 Da SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). TISSUE SPECIFICITY: Widely expressed. SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight
48.7kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-486M.
