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Millipore Active, N-Terminal, His6-Tagged Full Length Human Cdk6 Complexed With N-Terminal Gst-Tagged Full-Length Human Cyclin D3, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal, His6-tagged fulllength human cdk6 complexed with N-terminal GSTtagged full-length human cyclin D3
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal, His6-tagged full length human Cdk6 complexed with N-terminal GST-tagged full-length human Cyclin D3, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
expressed in Sf21 cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_001259.5
Entrez Gene Summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
Gene Symbol
CDK6
PLSTIRE
MGC59692
Protein Target
CDK6/cyclinD3
Purification Method
Glutathione-agarose
Target Sub-Family
CMGC
UniProt Number
Q00534
UniProt Summary
FUNCTION: SwissProt: Q00534 # Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins. SIZE: 326 amino acids; 36938 Da SIMILARITY: SwissProt: Q00534 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Molecular Weight
38kDa (cdk6) and 59kDa (cyclin D3)
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of histone H1
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-519M - Call for pricing and availability.
