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Millipore Inactive, N-Terminal Gst-Tagged, Recombinant, Human Mkk7β1 Amino Acids 2-End, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end
Product Information
Quality Level
MQ100
Applications
Application
Inactive, N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
expressed in E. coli
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_145185.2
Entrez Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
Gene Symbol
MAP2K7
MKK7
PRKMK7
MEK7
MAPKK7
JNKK2
Jnkk2
Protein Target
MKK7β1
Purification Method
Glutathione-agarose
Target Sub-Family
STE
UniProt Number
O14733
UniProt Summary
FUNCTION: SwissProt: O14733 # Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. COFACTOR: Magnesium. SIZE: 419 amino acids; 47485 Da SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). TISSUE SPECIFICITY: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. PTM: Activated by phosphorylation on Ser/Thr. SIMILARITY: SwissProt: O14733 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
Molecular Weight
74kDa
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of ATF2 (amino acids 19-96)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
