AG Scientific Blasticidin S HCl Solution in HEPES

AG Scientifics Blasticidin S HCl solution is a sterile filterate solution.

Description:

Blasticidin S HCl is an aminoacyl nucleoside antibiotic isolated fromStreptomyces griseochromogenes. It functions by inhibiting peptide bond formation at the ribosome in both eukaryotic and prokaryotic cells. It blocks hydrolysis of peptidyl-tRNA due to the large ribosomal subunits increased affinity for tRNA. Blasticidin S HCl has two deaminase genes: BSD from Aspergillus terreus and bsr from Bacillus cereus, where resistance is shown converting Blasticidin S HCl into a nontoxic deaminohydroxy derivative.

Concentration: 10 mg/mL in HEPES Buffer

Applications:

• Used as a selection agent for bls, bsr, or BSD resistance genes
• Prevents cell culture contamination
• Effective in antiviral, antitumor, and antifungal properties
• New role in Genome editing utilizing the CRISPR/Cas9 system.
• Gene selection antibiotic