AG Scientific Concanamycin A, 1 mg

Concanamycin A (isolated from Streptomyces sp.)is an antibiotic and a highly potent and specific cell-permeable inhibitor of V-ATPases that allows to rapidly inactivate this proton pump in living cells.Concanamycin A is more potent specific inhibitor than Bafilomycin A1. Inhibits the acidification of organelles including lysosomes and the Golgi apparatus.

Concanamycin A is reported to block cell surface expression of viral glycoproteins without affecting synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Studies have shown that Concanamycin A can cause apoptosis in Human oral squamous carcinoma cells.

Concanamycin A can be used for viral entry studies, it inhibits syncytium formation without affecting glycoprotein synthesis.