AG Scientific Hydroxychloroquine Sulfate, 10 mg

Description:

Hydroxychloroquine sulfate is an autophagy inhibitor.

A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types^1,2. Augments the anticancer activity of DNA-damaging chemotherapy³. Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells⁴. Has been used to treat alopecia successfully⁵. Clinically useful antimalaria agent. Cell permeable and active in vivo.

Research component for the novel coronavirus (COVID-19).Hydroxychloroquine have been found to be efficient on SARS-CoV-2 and reported to be efficient in Chinese COV-19 patients. It is evaluated that the role of hydroxychloroquine on respiratory viral loads. One study conducted by French, treatment of hydroxychloroquine with azithromycin was even more efficient for COV-19 elimination⁶.

References:

1. P Boya et Al. Mol. Cell Biol. 2005 25:1025

2. X Xie et Al. PLoS One 2013 8:e55096

3. Y Pan et Al. Clin. Cancer Res. 2011 150:3248

4. JY Jeong et Al. Immunology 2002 105:83

5. F Stephan et Al. J. Am. Acad. Dermatol. 2013 68:1048

6.“Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial”

7.“A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19”

8. “New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?”