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AG Scientific Hydroxychloroquine sulfate, 250 mg
List Price $267.85 Your Price $267.85
AG Scientific Hydroxychloroquine Sulfate (250 mg) is an autophagy inhibitor (Additional S&H Or Hazmat Fees May Apply) - AG
NETA PART: RPI-H-2451-250MG
MFG.PART: H-2451-250MG
UNSPSC: 51102800
Manufacturer: AG Scientific
AG Scientific
Description:
Hydroxychloroquine sulfate is an autophagy inhibitor.
A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types1,2. Augments the anticancer activity of DNA-damaging chemotherapy3. Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells4. Has been used to treat alopecia successfully5. Clinically useful antimalaria agent. Cell permeable and active in vivo.
Research component for the novel coronavirus (COVID-19).Hydroxychloroquine have been found to be efficient on SARS-CoV-2 and reported to be efficient in Chinese COV-19 patients. It is evaluated that the role of hydroxychloroquine on respiratory viral loads. One study conducted by French, treatment of hydroxychloroquine with azithromycin was even more efficient for COV-19 elimination6.
A guideline document by the Italian Society of Infectious and Tropical disease (Lombardy section) recommend the use of hydroxychloroquine 200 mg for 10 days, although the treatment may vary from 5 to 20 days according to clinical severity. The target population ranged from patients with mild respiratory symptoms and comorbidities to patients with severe respiratory failure7.
It is available for oral administration in the form of hydroxychloroquine sulfate and has pharmacokinetics similar to chloroquine, with rapid gastrointestinal absorption and renal elimination. It can be used in high doses for long periods with very good tolerance8.
Applications:
• Study of SARS-COV-2, COVID-19 and malaria
• Additional reading: Hydroxychloroquine for COVID-19: MIsconceptions in the Media
References:
1. P Boya et Al. Mol. Cell Biol. 2005 25:1025
2. X Xie et Al. PLoS One 2013 8:e55096
3. Y Pan et Al. Clin. Cancer Res. 2011 150:3248
4. JY Jeong et Al. Immunology 2002 105:83
5. F Stephan et Al. J. Am. Acad. Dermatol. 2013 68:1048
7.“A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19”
(Additional S&H Or Hazmat Fees May Apply) - AG| SKU | RPI-H-2451-250MG |
|---|---|
| Supplier Part Number | H-2451-250MG |
| UM | EA |
| UNSPSC | 51102800 |
| Manufacturer | AG Scientific |
| MSDS URL | Click here |
| Temperature | -20°C |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | AG |
| Qty | 1 |
| MinOrderQty | 1 |
| Width | 8 |
| Depth | 8 |
| Height | 8 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 747-36-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |